The S – phase is the synthesis phase of a cell cycle in which DNA doubles or replicates before starting mitosis.
This phase also ensures doubling of the centrosome (a microtubule-organising structure).
Mitosis is the stage of cell cycle where the cell divides its chromosomal content in 2 equal sets and separates its cytoplasm, to give rise to 2 new daughter cells.
If the chromosomal duplication doesn’t occur, the genetic material will not be divided equally in both the newly forming cells. Hence, mitosis will not occur.
Final Answer –
The correct answer is ‘No, mitosis cannot take place without DNA replication in S phase’