Combination of apoenzyme and coenzyme produces

Holoenzyme = Apoenzyme + Coenzyme

The holoenzyme is defined as apoenzyme in combination with the cofactor.

The combination of the apoenzyme and the coenzyme results in the formation of a functional enzyme which is called holoenzyme.

A prosthetic group is the non-amino acid component that is part of the structure of the heteroproteins or conjugated proteins, being tightly linked to the apoprotein.

The enzyme substrate complex is a temporary molecule formed when an enzyme comes into perfect contact with its substrate.

The bound substrate is converted to product by catalytic groups in the active site, forming the enzyme-product complex (EP).

Hence, the correct option is B: i.e., Holoenzymes